Seacrest interviews Arquette during On Air With Ryan Seacrest about who he is most looking forward to working with on Dancing With The Stars.
I look forward to having some time where I can just sit and talk to him. Because Alexis, my sister, is transgender. I grew up with her and I saw some of the struggles that she had. So, I feel like we could have a great connection on that and I have a ton of respect for doing this, it is a big challenge for everyone and it’s puts you out there. I just think it’s great.