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Ebola

Ebola466 posts

Ebola is a disease caused by an ebolavirus. Symptoms start two days to three weeks after contracting the virus, with a fever, sore throat, muscle pain and headaches. Vomiting, diarrhea and rash follow, along with decreased function of the liver and kidneys. Victims bleed both within the body and externally. From 1976 through 2013, the World Health Organization reported a total of 1,716 cases. In 2013 an outbreak started in Guinea, spreading to neighboring African countries and infectied doctors, some of who were transported back to the US for treatment. The virus continues to claim victims as it spreads to more countries.

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28 Aug, 2014

Mutating

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Multiple mutations are complicating the diagnosis and treatment of the disease. Genetic sequencing the virus from 78 patients, consisting of 99 samples, since the inception of the outbreak leads to the discovery that the virus is mutating during the course of the “Zaire” strain outbreak.  Researchers are gathering data to build a history of the particular strain, the disease possibly using bats as hosts since 2004. Gire:

We’ve uncovered more than 300 genetic clues about what sets this outbreak apart from previous outbreaks. Although we don’t know whether these differences are related to the severity of the current outbreak, by sharing these data with the research community, we hope to speed up our understanding of this epidemic and support global efforts to contain it.

27 Aug, 2014

Airlines suspend flights

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Airlines suspend flights through the three nation crisis zone. Air France temporarily suspends services to Sierra Leone, leaving its capital Freetown and Monrovia in neighbouring Liberia with just one regular service, from Royal Air Morocco. Air France:

In light of the analysis of the situation and as requested by the French government, Air France confirms it is maintaining its program of flights to and from Guinea and Nigeria.

Not all authorities agree with more severe isolation. Nabarro:

By isolating the country, it makes it difficult for the UN to do its work.

WHO expresses their concern in regards to aggressive isolation. Fukuda:

Pilots and others, as well as passengers, generally have very low risk of Ebola infection.

26 Aug, 2014

Takes ZMapp

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Pooley is treated with the experimental ZMapp Ebola drug. Dr Michael Jacobs, clinical director of infectious diseases at the Royal Free hospital in Hampstead, north London:

We had the opportunity to give him the ZMapp treatment. It is an experimental medicine, we made that absolutely clear in our discussions with him.

Dogs eat dead

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Rapid burials of possible Ebola victims lead to dogs digging up corpses and eating the remains. During the discovery, young men make efforts to contact the Healthy Ministry, which does not respond. The young men take matters into their own hands and try to kill the dogs, but some of the animals flee the scene. Resident:

We are very disappointed in the Health Ministry, especially the government that took an oath to defend and protect us; to see them act in such manner is unacceptable and we’ll never allow the government come to bury any longer. They will be resisted by us because I think the government has failed to protect us—why bring Ebola bodies and not bury them well?

Infected staff shuts lab

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A laboratory in Sierra Leone is shut down when a health worker is compromised by the Ebola virus. The World Health Organization is concerned the move may hinder efforts to combat the spread of the Ebola virus in the region. Up to this point, Ebola has infected 2,615 and killed a minimum of 1,427 people.

It’s a temporary measure to take care of the welfare of our remaining workers. After our assessment, they will return.

22 Aug, 2014

Hiding patients illegal

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Sierra Leone has voted to pass an amendment to its Health Act whereby people caught hiding Ebola patients could face possible jail time of up to two years. The amendment still needs to go for presidential approval. The country has been hit hard by the current outbreak with at least 392 deaths and 910 cases recorded.
Sierra Leone majority leader Ibrahim Bundu:

[Sierra Leone has suffered] abandonment and isolation from those we viewed to be our biggest friends in the region and beyond. These ugly developments are evidenced in the cancellations of flights, closing of borders, reduction of operational hours of banks and further isolation by shutting down businesses at the time of greatest need.

He said lawmakers would soon review the country’s partnerships “so as to form a permanent record of who are true friends are.”

21 Aug, 2014

Released from hospital

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Brantly is released from Hospital. He releases a statement (full text):

Today is a miraculous day. I am thrilled to be alive, to be well and to be reunited with my family. As a medical missionary, I never imagined myself in this position. When my family and I moved to Liberia last October to begin a two-year term working with Samaritan’s Purse, Ebola was not on the radar. We moved to Liberia because God called us to serve the people of Liberia.

After taking Amber and our children to the airport to return to the States on Sunday morning, July 20, I poured myself into my work even more than before—transferring patients to our new, bigger isolation unit; training and orienting new staff; and working with our Human Resources officer to fill our staffing needs. Three days later, on Wednesday, July 23, I woke up feeling under the weather, and then my life took an unexpected turn as I was diagnosed with Ebola Virus Disease. As I lay in my bed in Liberia for the following nine days, getting sicker and weaker each day, I prayed that God would help me to be faithful even in my illness, and I prayed that in my life or in my death, He would be glorified.

I did not know then, but I have learned since, that there were thousands, maybe even millions of people around the world praying for me throughout that week, and even still today. I cannot thank you enough for your prayers and your support. But what I can tell you is that I serve a faithful God who answers prayers.

Thank you to Emory University Hospital and especially to the medical staff in the isolation unit. You treated me with such expertise, yet with such tenderness and compassion. For the last three weeks you have been my friends and my family. And so many of you ministered to me not only physically, but also spiritually, which has been an important part of my recovery. I will never forget you and all that you have done for me. And thank you to my family, my friends, my church family and to all who lifted me up in prayer, asking for my healing and recovery. Please do not stop praying for the people of Liberia and West Africa, and for a quick end to this Ebola epidemic.

20 Aug, 2014

Kenya to close borders

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Kenya will be closing its borders on Wednesday August 20 to people travelling from Guinea, Sierra Leone and Liberia due to the spread of the virus. Kenya is at high risk as it is a major transport hub. Kenya’s health secretary said Kenyans and medical workers flying in from those states would still be allowed in. Kenyan Airways says it will stop flights to Liberia and Sierra Leone when the ban comes in. Kenyan Health Minister James Macharia said it was “in the interest of public health” and warned that Kenyans and health workers who had returned from the three west African states would face “strict checks” and would be quarantined if necessary.

18 Aug, 2014

Khan not given Ebola drug

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ebola-khan-not-given-drugAfter Khan’s death, it is discovered that he was not given ZMapp or asked to be a test case although an experimental dose was available. A Canadian team of scientists who had developed ZMapp were testing a dose for resistance to the African climate at a location within reach of the Sierra Leone field hospital where Khan was treated and offered to use it to treat him. However as the drug was untested and Khan’s immune system was fighting the virus, it was decided that the drug had a higher risk of killing him. His colleague, Dr. Daniel Bausch:

You had a person who was sick, and a drug never used on humans before, it wasn’t approved. There were lots of questions to be asked and no easy answers

He believes the final decision was with the field doctors at the hospital but says he disagrees with the refusal of the drug, especially as it was used on :

I do want it to be clear that these were difficult, delicate decisions that people in a stressful situation had to make. But I’m not going to deny that I disagree with the decision they made.

16 Aug, 2014

Health care facilty attacked

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A health care facility in Monrovia, Liberia is attacked, causing a number of patients to flee the facility, all of them infected with Ebola. Some patients chose not to leave. The perpetrators made off with mattresses and equipment. No injuries have been reported. Liberian National Police:

It was an attack from people afraid of Ebola

14 Aug, 2014

Bioweapon fears create serum

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The San Diego-based Mapp Biopharmaceutical develops ZMapp with the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) due to fears Ebola could be used as a bioweapon. ZMapp is made from two serums, MB-003 developed and ZMAb, made by Canadian company Defyrus Inc., and combined by Mapp Biopharmaceutical’s commercial arm LeafBio. MB-003 uses three chimera antibodies developed in mice, with human DNA spliced in, and grown in a genetically engineered indigenous Australian tobacco plant. ZMab was developed in a similar way.

12 Aug, 2014

19th century serology

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Harvard Medical School associate professor of Global Health and Social Medicine Dr. Scott Podolsky writes in Annals of Internal Medicine that ZMapp is inspired by serology techniques developed in the 1890s after Louis Pasteur and Robert Koch began to identify the agents of diseases like anthrax, diptheria and pneumonia:

From the 1890s onward, this model of production – expose an animal (guinea pig, rabbit, cow, horse, etc.) to an identified microbial pathogen, generate antibodies (or use convalescent serum from former patients), and then ‘passively’ transfer the pre-formed antibodies to an exposed animal or person – could be expanded to such feared and prevalent diseases as pneumococcal pneumonia and meningococcal meningitis.

11 Aug, 2014

Drug supply exhausted

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The supply of ZMApp, an experimental Ebola drug has been used to treat the two Americans as well as a Spanish Priest and two Doctors in West African countries is exhausted. Other countries have called ZMapp and they have complied with requests to the best of their ability. The drug has been provided at no cost.

It is our understanding that all patients offered treatment, treated, or expected to be treated were or are highly capable of providing informed consent for the use of an experimental drug not yet evaluated for safety in animals or people.

ZMapp along with their partners are working to increase production as quickly as possible. However, Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases says:

How can a couple of doses control an outbreak with hundreds and hundreds of people? You don’t control the epidemic with two or three doses.

10 Aug, 2014

Panic over sick passenger

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A federal Customs and Border Protection agent says the arrival of a sick passenger believed to be from Liberia last Saturday caused confusion at Newark. The flight arrived at the gate and most passengers were allowed into the customs hall, while the sick passenger was taken to a hospital. For a low-level bomb scare, the plane is parked away from the airport.Airport managers went on the public address system and asked the passengers to separate themselves from people who had been on other flights and were not exposed to the vomiting patient.

A panic ensued. It was a disaster

8 Aug, 2014

Nigeria: State of Emergency

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Nigeria declares a State of Emergency after seven cases of Ebola are confirmed in the country after a man arriving from Liberia fell sick. Two of the confirmed cases die while several people who have come into contact with the man are under surveillance.

7 Aug, 2014

Trial drug use sparks controversy

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The World Health Organisation announces it is convening a special meeting next week to explore using experimental drugs in the West African outbreak, after two health workers from the US charity Samaritan’s Purse are treated with a drug called ZMapp. The decision to use an experimental drug to treat two Americans infected with Ebola, while nearly 1 000 Africans have already died from the deadly epidemic, has sparked controversy, but US experts say it is ethically justified.

The experimental drug is still in an extremely early phase of development and had only been tested previously on monkeys. It has never been produced on a large scale. There is no proven treatment or cure for Ebola. Samaritan’s Purse members Kent Brantly and Nancy Writebol, however, have shown improvements since taking the drug.

6 Aug, 2014

Arrives in US

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Writebol, the second American who contracted Ebola while working with a missionary group in Liberia, is airlifted to Emory hospital in Atlanta for treatment. The aid worker, 59, is the second American to be flown into the US for treatment. David Writebol:

Now we have a real reason to be hopeful.

Pledges $200 million

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The World Bank pledges $200m in emergency aid to Liberia, Guinea and Sierra-Leone, in a bid to counter further spread of the deadly virus. Jim Yong Kim, the president of the World Bank, says that he is ” deeply saddened” by the progress of the epidemic thus far. The funds will be used to undertake numerous relief activities including providing medical supplies, paying staff and driving a campaign that will contain the epidemic.Yong Kim:

I have been monitoring (Ebola’s) deadly impact around the clock and I’m deeply saddened at how it has ravaged health workers, families and communities, disrupted normal life and has led to a breakdown of already weak health systems in the three countries.

Patients respond to trial drug

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Both US patients appear to be responding well to experimental drugs provided by San Diego-based Mapp Biopharmaceutical. The Company is manufacturing more of the drug, while conducting clinical trials. Larry Zeitlin, the president of Mapp:

It’s absolutely overwhelming. We are discussing with the F.D.A. the right path to make the drug available to people as quickly and safely as possible.

Major decisions on how and where the drug will go are being discussed. Dr. Whaley:

We definitely would like to ramp up to have an impact on the Ebola epidemic. We’re not decision makers on many of these issues. There are regulatory and legal issues that have to be addressed.

5 Aug, 2014

CDC concerned about spread

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The CDC is now concerned about the risk of Ebola spreading beyond Guinea, Nigeria, Sierra Leone and Liberia. Dr. Skinner, an infectious disease specialist from the organization, says that travelers could unknowingly transfer the deadly virus beyond more international borders. Dr. Rob Dretler, CDC:

We know what to do and can completely isolate them but someone coming home who doesn’t know they are sick and is here a few days and gets sick, that’s the risk.