In this animated comedy, Brand voices Dr. Nefario, a friendly and good-natured scientist who works with the main character, Gru, who is voiced by Steve Carell. He lives in an underground laboratory, in which he builds various gadgets and machines for Gru in his mission to steal the moon. The film also features the voices of Jason Segel, Miranda Cosgrove, and Julie Andrews.
Dr. Nefario in this movie is a mentor and also a sort of bumbling half-wit. You know they say, genius and madness are really close to each other – they’re not, are they – because I know some mad people and they’re idiots, and I think that Dr. Nefario is like an idiot. He’s sort of old, makes terrible mistakes, there are wonderful contraptions, some of which were needlessly manufactured on account of mishearing information.