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Zika VirusScientific Discovery

First well-documented infection report

1964

The first well-documented report of human Zika infection is reported, when researcher D.I.H. Simpson describes his own occupationally acquired illness at age 28. The infection starts with mild headache. The next day, a rash covers his face, neck, trunk, and upper arms, and spreads to his palms and soles. Transient fever, malaise, and back pain develops. By the evening of the second day of illness the fever abates, the rash fades, and he feels better. By day three, he feels well and only the rash remains, which disappeared over the next two days. The virus is isolated from serum collected while he has the fever.

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