Graham gives the keynote speech to Pycon, the annual conference of Python programmers. He later reworks the speech as an essay, Frighteningly Ambitious Startup Ideas.
One of the more surprising things I’ve noticed while working on Y Combinator is how frightening the most ambitious startup ideas are. Any one of them could make you a billionaire. That might sound like an attractive prospect, and yet when I describe these ideas you may notice you find yourself shrinking away from them.
He discusses seven ideas: A new search engine, replacing email, replacing universities, movie content on the net, the next Steve Jobs, bringing back Moore’s Law, and automated medical diagnosis.